Super interesting topic. I've also searched this as I am fascinated with the idea of breeding a Japanese maple cultivar that can thrive in zones 9 and above. There's more research on this topic within commercial fruiting plants such as peaches, thats probably where the money is.
I think a good method for conducting research would be to collect as many Japanese maple cultivars as possible, then propagate maybe 2-10 cuttings from each cultivar. From there, keep them in a temperature controlled environment with a fixed number of chill hours per year and record which cultivars do best under N chill hours.
From there, start crossing maples that have the most promising traits for low chill requirement, heat tolerance, and any additional traits that may be beneficial such as growth speed, vigor or attractiveness. I've read that plants grown from seed have a range of chill requirements that averages out to be equal to the mother plant. So it is possible to select for the lowest chill requirement seedlings over generations.