You have active growth on the parts you want to keep? If yes, most likely is safe to remove unwanted shoots and branches. It looks safe from the photo.
Blueberry has a tendency to abandon older branches (trunks) in favor of unbranched younger shoots. This is how a blueberry bush, renews itself and why they are bushes in nature rather than trees. To keep older branches healthy, remove young, unbranched shoots, especially shoots directly from the root system. Do plan an eventual succession for branches or trunks. I don't know how long a single trunk can be maintained, but 40 years is possible. I have cut out 40 year old trunks from bushes, in pruning for fruit production. To keep an older trunk, get rid of the "suckers" from the roots.
Keep in mind, for blueberry the long lived part is the root system. A blueberry field can be productive for 100 years. But pruning for fruit production means most wood will be between 4 to 10 years old. Trunks older than 10 years yield less fruit, by weight. So pruning for fruit encourages new shoots from roots to replace old trunks in a regular succession.
Dude, you're not dead! AWESOME!
